Biliary decompression promotes Kupffer cell recovery in obstructive jaundice.

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Biliary decompression promotes Kupffer cell recovery in obstructive jaundice.

BACKGROUND Jaundiced patients undergoing surgical procedures have an increased risk of Gram negative sepsis with potential morbidity and mortality. Depressed Kupffer cell clearance capacity (KCCC) predisposes jaundiced patients to endotoxaemia and its sequelae. Biliary decompression remains the main therapeutic strategy in obstructive jaundice. AIMS This study investigates the efficacy of int...

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We examined the effect of prolonged bile duct obstruction, and subsequent biliary decompression, on biochemical and metabolic parameters, using a reversible jaundice model in male Fischer 344 rats. The animals were studied after biliary obstruction for varying periods (4 days, one week, and two weeks) and following decompression. They were sacrificed one or two weeks following decompression. Al...

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ژورنال

عنوان ژورنال: Gut

سال: 1996

ISSN: 0017-5749

DOI: 10.1136/gut.38.6.925